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Recent publications

Novel Drug Delivery Unit

Recent Publications and conference presentations

Peer reviewed publications in ISI Journals over the last 5 years (2020 - to date)

  1. Nyandoro, V.O., Peters, X.Q., Omolo, C.A., Gafar, M.A. and Govender, T., 2025. Targeting the ADAM10-Alpha Hemolysin Axis Using Ascorbyl Stearate as a Potential Therapy in S. aureus Infections: In Silico and MST Studies. ACS Omega. (IF 4.3).
  2. Omolo, C.A., Ismail, E.A., Amuhaya, E.K., Fasiku, V., Nwabuife, J.C., Mohamed, M., Gafar, M.A., Kalhapure, R. and Govender, T., 2025. Revolutionizing drug delivery: The promise of surface functionalized dendrimers in overcoming conventional limitations. European Polymer Journal, p.114079. (IF 6.3).
  3. Ismail, E.A., Nyandoro, V.O., Omolo, C.A. and Govender, T., 2025. Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy. Advanced Healthcare Materials, p.2501146. (IF 9.6).
  4. Oboh, M., Elhassan, E., Koorbanally, N.A., Govender, L., Siwela, M., Govender, T. and Mkhwanazi, B.N., 2025. Characterisation and In Vitro Drug Release Profiles of Oleanolic Acid-and Asiatic Acid-Loaded Solid Lipid Nanoparticles (SLNs) for Oral Administration. Pharmaceutics, 17(6), p.723. (IF 5.5).
  5. Dlamini, S., Omolo, C.A., Elhassan, E., Ismail, E.A., Peters, X.Q., Kassam, S.Z., Gafar, M.A., Govender, J., Chemonges, C.C. and Govender, T., 2025. Enhancing activity and overcoming ciprofloxacin resistance via multifunctional nanostructured lipid carriers. Journal of Drug Delivery Science and Technology, p.106933. (IF 4.9).
  6. Gafar, M.A., Omolo, C.A., Ibrahim, U.H., Elamin, G., Tageldin, A., Elhassan, E., Ismail, E.A., Mackraj, I. and Govender, T., 2025. Hyaluronic acid-silybin conjugate for the preparation of multifunctional, biomimetic, vancomycin-loaded self-assembled polymersomes against bacterial sepsis. International Journal of Biological Macromolecules, p.140152. (IF 8.5).
  7. Gafar, M. A., Omolo, C. A., Ibrahim, U. H., Peters, X. Q., Ismail, E. A., Khan, R., & Govender, T. (2025). Antimicrobial peptide-fucoidan nanoplexes: A novel multifunctional biomimetic nanocarrier for enhanced vancomycin delivery against bacterial infections and sepsis. International Journal of Pharmaceutics, 125344. (IF 5.2).
  8. Nyandoro, V.O., Ismail, E.A., Tageldin, A., Gafar, M.A., Peters, X.Q., Mautsoe, R., Omolo, C.A. and Govender, T., 2025, Potential of nanocarrier-mediated delivery of vancomycin for MRSA infections. Expert opinion on drug delivery. (IF 5.0).
  9. Elhassan, E., Omolo, C.A., Gafar, M.A., Ismail, E.A., Ibrahim, U.H., Khan, R., Lesouhaitier, M., Kubes, P. and Govender, T., 2025. Multifunctional hyaluronic acid-based biomimetic/pH-responsive hybrid nanostructured lipid carriers for treating bacterial sepsis. Journal of Biomedical Science, 32(1), p.19. (IF 12.1).
  10. Peters, X.Q., Omolo, C.A. and Govender, T., 2025. Paving the Way for NLRP3 Inflammasome Inactivation Using ADAM10 and Alpha-Hemolysin: An In Silico Investigation. ACS omega, 10(8), pp.7981-7988. (IF 4.1).
  11. Ibrahim, U.H., Gafar, M.A., Khan, R., Tageldin, A., Govender, T. and Mackraj, I., 2024. Engineered extracellular vesicles coated with an antimicrobial peptide for advanced control of bacterial sepsis. Journal of Extracellular Biology, 3(8), p.e70000. (Research Impact Score 1.2).
  12. Chetty, K., Peters, X.Q., Omolo, C.A., Ismail, E.A., Gafar, M.A., Elhassan, E., Kassam, S.Z., Govender, J., Dlamini, S. and Govender, T., 2024. Multifunctional Dual Enzyme-Responsive Nanostructured Lipid Carriers for Targeting and Enhancing the Treatment of Bacterial Infections. ACS Applied Bio Materials, 8(1), pp.548-569. (IF 4.7).
  13. Elhassan, E., Omolo, C.A., Gafar, M.A., Kiruri, L.W., Ibrahim, U.H., Ismail, E.A., Devnarain, N. and Govender, T., 2024. Disease-Inspired Design of Biomimetic Tannic Acid–Based Hybrid Nanocarriers for Enhancing the Treatment of Bacterial-Induced Sepsis. Molecular Pharmaceutics, 21(10), pp.4924-4946. (IF 4.5).
  14. Ismail, E.A., Omolo, C.A., Gafar, M.A., Khan, R., Nyandoro, V.O., Yakubu, E.S., Mackraj, I., Tageldin, A. and Govender, T., 2024. Novel peptide and hyaluronic acid coated biomimetic liposomes for targeting bacterial infections and sepsis. International Journal of Pharmaceutics, 662, p.124493. (IF 5.2).
  15. Tageldin, A., Omolo, C.A., Nyandoro, V.O., Elhassan, E., Kassam, S.Z., Peters, X.Q. and Govender, T., 2024. Engineering dynamic covalent bond-based nanosystems for delivery of antimicrobials against bacterial infections. Journal of Controlled Release, 371, pp.237-257. (IF 11.5).
  16. Gafar, M.A., Omolo, C.A., Elhassan, E., Ibrahim, U.H. and Govender, T., 2024. Applications of peptides in nanosystems for diagnosing and managing bacterial sepsis. Journal of Biomedical Science, 31(1), p.40. (IF 12.1).
  17. Ismail, E.A., Omolo, C.A., Gafar, M.A., Khan, R., Nyandoro, V.O., Salifu, E.Y. and Govender, T., 2024. Multi-functional pH-responsive and biomimetic chitosan-based nanoplexes for targeted delivery of ciprofloxacin against bacterial sepsis. International Journal of Biological Macromolecules, 262, p.130046. (IF 8.5).
  18. Piao, Y.Z., Su, L., Hu, X., He, W., Hu, X., Omolo, C.A., Govender, T., Li, H., Xue, H., Ge, Y. and Liu, Y., 2024. One-component lipidic bicontinuous nanospheres as a smart drug loading platform to eradicate candida biofilms in oral and vaginal infection. Nano Today, 54, p.102123. (IF 10.9).
  19. Osman, N., Omolo, C.A., Gafar, M.A., Devnarain, N., Rambharose, S., Ibrahim, U.H., Fasiku, V.O. and Govender, T., 2024. Niosomes modified with a novel pH-responsive coating (mPEG-OA) enhance the antibacterial and anti-biofilm activity of vancomycin against methicillin-resistant Staphylococcus aureus. Nano Express, 5(1), p.015008. (IF 2.7).
  20. Nyandoro, V.O., Omolo, C.A., Ismail, E.A., Yong, L. and Govender, T., 2023. Inflammation-responsive Drug Delivery Nanosystems for Treatment of Bacterial-induced Sepsis. International Journal of Pharmaceutics, 644,123346.  (IF 5.2).
  21. Mohammed, M., Ibrahim, U.H., Aljoundi, A., Omolo, C.A., Devnarain, N., Gafar, M.A., Mocktar, C. and Govender, T., 2023. Enzyme-responsive biomimetic solid lipid nanoparticles for antibiotic delivery against hyaluronidase-secreting bacteria. International Journal of Pharmaceutics, 640, p.122967. (IF 5.2).
  22. Zhan, Y., Hu, X., Li, Y., Wang, Y., Chen, H., Omolo, C.A., Govender, T., Li, H., Huang, F., Shi, L. and Hu, X., 2023. Antimicrobial hybrid amphiphile via dynamic covalent bonds enables bacterial biofilm dispersal and bacteria eradication. Advanced Functional Materials, 33(23), p.2214299. (IF 19).
  23. Osman, N., Mohammed, M., Omolo, C.A., Ibrahim, U.H., Gafar, M.A., Rambharose, S., Devnarain, N., Kiruri, L.W., Nwabuife, J. and Govender, T., 2023. Hyaluronidase inhibitor surface-modified niosomes: An efficient strategy for antibacterial and anti-biofilm drug delivery. Materialia, 30, p.101826. (IF 2.9).
  24. Nwabuife, J.C., Hassan, D., Pant, A.M., Devnarain, N., Gafar, M.A., Osman, N., Rambharose, S. and Govender, T., 2023. Novel vancomycin free base–Sterosomes for combating diseases caused by Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus infections (S. Aureus and MRSA). Journal of Drug Delivery Science and Technology, 79, p.104089.) (IF 4.9).
  25. Nwabuife, J.C., Omolo, C.A., Abdallah, E.I., Gafar, M.A., Mohammed, M., Rambharose, S. and Govender, T., 2023. P04 Dual pH/enzyme-responsive capsules of ciprofloxacin; a strategy to maximize the efficacy against infection causing superbugs such as MRSA and Pseudomonas aeruginosa. JAC-Antimicrobial Resistance, pp.dlac133-008. (IF 3.7).
  26. Ismail, E.A., Devnarain, N., Govender, T. and Omolo, C.A., 2022. Stimuli-responsive and biomimetic delivery systems for sepsis and related complications. Journal of Controlled Release, 352, pp.1048-1070. (IF 11.5).
  27. Elhassan, E., Devnarain, N., Mohammed, M., Govender, T. and Omolo, C.A., 2022. Engineering hybrid nanosystems for efficient and targeted delivery against bacterial infections. Journal of Controlled Release, 351, pp.598-622. (IF 11.5).
  28. Ibrahim, U.H., Devnarain, N., Mohammed, M., Omolo, C.A., Gafar, M.A., Salih, M., Pant, A., Shunmugam, L., Mocktar, C., Khan, R. and Oh, J.K., 2022. Dual acting acid-cleavable self-assembling prodrug from hyaluronic acid and ciprofloxacin: a potential system for simultaneously targeting bacterial infections and cancer. International Journal of Biological Macromolecules, 222, pp.546-561. (IF 8.5).
  29. Makhathini, S.S., Omolo, C.A., Kiruri, L.W., Walvekar, P., Devnarain, N., Mocktar, C. and Govender, T., 2022. Synthesis of pH-responsive dimethylglycine surface-modified branched lipids for targeted delivery of antibiotics. Chemistry and Physics of Lipids, 249, p.105241. (IF 2.8).
  30. Nwabuife, J.C., Omolo, C.A. and Govender, T., 2022. Nano delivery systems to the rescue of ciprofloxacin against resistant bacteria “E. coli; P. aeruginosa; Saureus; and MRSA” and their infections. Journal of Controlled Release, 349, pp.338-353. (IF 11.5).
  31. Fasiku, V.O., Omolo, C.A., Kiruri, L.W., Devnarain, N., Faya, M., Mocktar, C. and Govender, T., 2022. A hyaluronic acid-based nanogel for the co-delivery of nitric oxide (NO) and a novel antimicrobial peptide (AMP) against bacterial biofilms. International Journal of Biological Macromolecules, 206, pp.381-397. (IF 8.5).
  32. Mohammed, M., Devnarain, N., Elhassan, E. and Govender, T., 2022. Exploring the applications of hyaluronic acid‐based nanoparticles for diagnosis and treatment of bacterial infections. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 14(4), p.e1799. (IF 8.2).
  33. Sayyad, N., Maji, R., Omolo, C.A., Ganai, A.M., Ibrahim, U.H., Pathan, T.K., Devnarain, N., Karpoormath, R., Dhawan, S., Obakachi, V.A. and Merugu, S.R., 2021. Development of niosomes for encapsulating captopril-quercetin prodrug to combat hypertension. International journal of pharmaceutics, 609, p.121191. (IF 5.2).
  34. Osman, N., Devnarain, N., Omolo, C.A., Fasiku, V., Jaglal, Y. and Govender, T., 2022. Surface modification of nano‐drug delivery systems for enhancing antibiotic delivery and activity. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 14(1), p.e1758. (IF 8.2).
  35. Omolo, C.A., Hassan, D., Devnarain, N., Jaglal, Y., Mocktar, C., Kalhapure, R.S., Jadhav, M. and Govender, T., 2021. Formulation of pH responsive multilamellar vesicles for targeted delivery of hydrophilic antibiotics. Colloids and Surfaces B: Biointerfaces, 207, p.112043. (IF 5.6).
  36. Maji, R., Omolo, C.A., Jaglal, Y., Singh, S., Devnarain, N., Mocktar, C. and Govender, T., 2021. A transferosome-loaded bigel for enhanced transdermal delivery and antibacterial activity of vancomycin hydrochloride. International Journal of Pharmaceutics, 607, p.120990. (IF 5.2).
  37. Devnarain, N., Waddad, A.Y., de la Torre, B.G., Albericio, F. and Govender, T., 2021. Novel biomimetic human tlr2-derived peptides for potential targeting of lipoteichoic acid: an in silico assessment. Biomedicines, 9(8), p.1063. (IF 3.9).
  38. Fasiku, V.O., Omolo, C.A., Devnarain, N., Ibrahim, U.H., Rambharose, S., Faya, M., Mocktar, C., Singh, S.D. and Govender, T., 2021. Chitosan-based hydrogel for the dual delivery of antimicrobial agents against bacterial methicillin-resistant Staphylococcus aureus biofilm-infected wounds. ACS omega, 6(34), pp.21994-22010. (IF 4.3).
  39. Ibrahim, U.H., Devnarain, N. and Govender, T., 2021. Biomimetic strategies for enhancing synthesis and delivery of antibacterial nanosystems. International Journal of Pharmaceutics, 596, p.120276. (IF 5.2).
  40. Omolo, C.A., Megrab, N.A., Kalhapure, R.S., Agrawal, N., Jadhav, M., Mocktar, C., Rambharose, S., Maduray, K., Nkambule, B. and Govender, T., 2021. Liposomes with pH responsive ‘on and off’switches for targeted and intracellular delivery of antibiotics. Journal of liposome research, 31(1), pp.45-63. (IF 5.0).
  41. Ibrahim, U.H., Devnarain, N., Omolo, C.A., Mocktar, C. and Govender, T., 2021. Biomimetic pH/lipase dual responsive vitamin-based solid lipid nanoparticles for on-demand delivery of vancomycin. International Journal of Pharmaceutics, 607, p.120960. (IF 5.2).
  42. Jaglal, Y., Osman, N., Omolo, C.A., Mocktar, C., Devnarain, N. and Govender, T., 2021. Formulation of pH-responsive lipid-polymer hybrid nanoparticles for co-delivery and enhancement of the antibacterial activity of vancomycin and 18β-glycyrrhetinic acid. Journal of Drug Delivery Science and Technology, 64, p.102607. (IF 4.9).
  43. Nwabuife, J.C., Pant, A.M. and Govender, T., 2021. Liposomal delivery systems and their applications against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus. Advanced Drug Delivery Reviews, 178, p.113861. (IF 17.6).
  44. Pant, A., Mackraj, I. and Govender, T., 2021. Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology. Journal of Biomedical Science, 28(1), pp.1-30. (IF 12.1).
  45. Salih, M., Walvekar, P., Omolo, C.A., Elrashedy, A.A., Devnarain, N., Fasiku, V., Waddad, A.Y., Mocktar, C. and Govender, T., 2021. A self-assembled polymer therapeutic for simultaneously enhancing solubility and antimicrobial activity and lowering serum albumin binding of fusidic acid. Journal of Biomolecular Structure and Dynamics, 39(17), pp.6567-6584 (IF 2.7).
  46. Devnarain, N., Osman, N., Fasiku, V.O., Makhathini, S., Salih, M., Ibrahim, U.H. and Govender, T., 2021. Intrinsic stimuli‐responsive nanocarriers for smart drug delivery of antibacterial agents—An in‐depth review of the last two decades. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 13(1), p.e1664. (IF 8.2).
  47. Faya, M., Hazzah, H.A., Omolo, C.A., Agrawal, N., Maji, R., Walvekar, P., Mocktar, C., Nkambule, B., Rambharose, S., Albericio, F. and de la Torre, B.G., 2020. Novel formulation of antimicrobial peptides enhances antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA). Amino Acids, 52, pp.1439-1457. (IF 3.1).
  48. Gannimani, R., Walvekar, P., Naidu, V.R., Aminabhavi, T.M. and Govender, T., 2020. Acetal containing polymers as pH-responsive nano-drug delivery systems. Journal of controlled release, 328, pp.736-761. (IF 11.5).
  49. Hassan, D., Omolo, C.A., Fasiku, V.O., Elrashedy, A.A., Mocktar, C., Nkambule, B., Soliman, M.E. and Govender, T., 2020. Formulation of pH-responsive quatsomes from quaternary bicephalic surfactants and cholesterol for enhanced delivery of vancomycin against methicillin resistant Staphylococcus aureus. Pharmaceutics, 12(11), p.1093. (IF 5.5).
  50. Salih, M., Omolo, C.A., Devnarain, N., Elrashedy, A.A., Mocktar, C., Soliman, M.E. and Govender, T., 2020. Supramolecular self-assembled drug delivery system (SADDs) of vancomycin and tocopherol succinate as an antibacterial agent: in vitro, in silico and in vivo evaluations. Pharmaceutical Development and Technology, 25(9), pp.1090-1108. (IF 2.8).
  51. Omolo, C.A., Soni, N., Fasiku, V.O., Mackraj, I. and Govender, T., 2020. Update on therapeutic approaches and emerging therapies for SARS-CoV-2 virus. European Journal of Pharmacology, 883, p.173348. (IF 4.7).
  52. Makhathini, S.S., Omolo, C.A., Gannimani, R., Mocktar, C. and Govender, T., 2020. pH-responsive micelles from an oleic acid tail and propionic acid heads dendritic amphiphile for the delivery of antibiotics. Journal of Pharmaceutical Sciences, 109(8), pp.2594-2606. (IF 3.8).
  53. Fasiku, V., Omolo, C.A. and Govender, T., 2020. Free radical-releasing systems for targeting biofilms. Journal of Controlled Release, 322, pp.248-273. (IF 11.5).
  54. Hassan, D., Omolo, C.A., Fasiku, V.O., Mocktar, C. and Govender, T., 2020. Novel chitosan-based pH-responsive lipid-polymer hybrid nanovesicles (OLA-LPHVs) for delivery of vancomycin against methicillin-resistant Staphylococcus aureus infections. International journal of biological macromolecules, 147, pp.385-398. (IF 8.5).
  55. Salih, M., Omolo, C.A., Agrawal, N., Walvekar, P., Waddad, A.Y., Mocktar, C., Ramdhin, C. and Govender, T., 2020. Supramolecular amphiphiles of beta-cyclodextrin and oleylamine for enhancement of vancomycin delivery. International Journal of Pharmaceutics, 574, p.118881. (IF 5.2).
  56. Sonawane, S.J., Kalhapure, R.S., Jadhav, M., Rambharose, S., Mocktar, C. and Govender, T., 2020. AB2-type amphiphilic block copolymer containing a pH-cleavable hydrazone linkage for targeted antibiotic delivery. International Journal of Pharmaceutics, 575, p.118948. (IF 5.2).